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| - As concerns compositions that trigger the maturation phase, document E1 mentions the use of conditioned medium for the maturation of dendritic cells from human blood (see page 3S, left column, second paragraph with the heading Maturation, last two sentences) and of two specific cytokines, GM-CSF and TNF-alpha, for cells cultured from other sites, e.g. spleen, lung, heart, and kidney (see page 3S
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