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  • In another embodiment, the combination of the two moieties, Z-CINN and HX, A, can be achieved through the coupling of either a cinnamate halide or anhydride or cinnamic acid with a biologically active molecule (HX, A) such as a drug having a hydroxyl group in the presence of a dehydrating agent such as a base or a mixture of bases, generating the prodrug composition.
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