receptor gene 5HTR 2A (Ser 1438 and Ser 102) shows a significant increaseof the allele frequency in the Prakrithi having an association of Kapha.DRD2*B2 allele and DRD2*A2 and 5HTR 1B G allele are influenced by Vatha.DRD2 S311C and DRD3 S9G are influenced by Kapha.Dopamine is a chemical naturally produced in the body mainly in nervoustissue and adrenal glands.