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  • or heterarylene (including up to four optional substituents, R13, R14, R15, and R15A as defined above), [1356] R??? is a standard carboxylic acid protecting group, such as C1-C6-alkyl or benzyl and Lea is a leaving group, such as chloro, bromo, iodo, methanesulfonyloxy, toluenesulfonyloxy or the like. [1357] Step 1 is an alkylation of a phenol moiety.
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