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  • Furthermore, incontrast to drug trials, traditional placebo-controlled tri-als are not practical with devices such as VNS, DBS,RNS, or cooling, due to the patients??? ability to perceivewhen stimulation or cooling is ???on,??? In some studies,sham controls with the same invasive procedure, but nostimulation have been used, but this does not resolve theproblem of sensing the stimulus.
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