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  • Signal transduction pathways are rapidly activated following exposure to DNA damaging agents and other cellular stresses, and these pathways affect processes such as gene transcription and cell cycle progression (Hartwell and Weinert (1989) Science 246:629???634; Hartwell and Kastan (1994) Science 266:1821???1828; Elledge (1996) Science 274:1664???1672).
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