When binding agent such as hydroxy propyl cellulose was excluded for a trial containing unmicronized hydrophobic drug felodipine (NLT 75 microns) and the excipients were ??-cyclodextrin (unmicronized 227.64 microns) and water, at an operating pressure of 10,000 psi and three passes, the particle size of the output material was NMT 2.8 microns for 90% of the distribution.