Adjusting for age, sex, body mass index, smoking status, Age-Related Maculopathy Susceptibility 2 and Complement Factor H genotypes and other factors, mean IMT was associated with the 10-year incidence of early AMD (odds ratio per 0.1 mm IMT 1.11, 95% confidence interval 1.00???1.21, P value=0.03) and late AMD (1.27, 1.10???1.47, P=0.001).