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  • Sclerostin, whose expression is regulated by mechanical loading and factors such as prostaglandins, estrogen, and parathyroid hormone (48, 67, 70,???74), keeps both pathways in check and plays a key role in maintaining bone homeostasis.In conclusion, we found that besides the inhibitory effect sclerostin exerts on the Wnt signaling pathway in osteoblasts and osteocytes by binding LRP5/6 at the cel
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