DLco is the lung diffusing capacity for carbon monoxide, and is expressed as mL CO/mm Hg/second. [0060] In some embodiments, an ???effective amount??? of a TLR agonist is an amount effective to increase progression-free survival period (arrests progression of the interstitial lung disease), e.g., the time from baseline (e.g., a time point from 1 day to about 30 days before beginning of treatment)