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  • Sclerosis can affect the skin and subcutaneous tissues including fasciae, joints and the musculoskeletal system with varying degrees of severity and is a diagnostic feature of chronic GVHD. Early involvement of fasciae and tendons is associated with edema and an eosinophilic infiltrate, with later progression to fibrosis and joint contractures, most commonly in fingers, wrists, shoulders, elbows a
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