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  • When the compound desired is of Formula I where R2 is of Formula II and R3 is other than H, reacting rapamycin or a derivative thereof with an organic radical attached to a leaving group R3 --Z where R3 is an organic radical as defined in Formula I which is desired as the O-substituent, and Z is the leaving group in the presence of a suitable acid, or in the presence of a suitable base; iii.
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