Those most at risk are people, especially older adults, who take antibiotics and also get medical care.Source: <a href="http://www.cdc.gov/hai/organisms/cdiff/Cdiff-patient.htmlPrevention">http://www.cdc.gov/hai/organisms/cdiff/Cdiff-patient.htmlPrevention</a> of C. difficileTo help prevent the spread of C. difficile, hospitals and other health care facilities follow strict infection-control guidelines.