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  • After the reaction is completed, the solution is neutralized with such as hydrochloric acid to make pH 1 to 6, acetone is distilled up to distillation temperature 100??? C., and the obtained is used as it is for the next Process b, or, if Compound I is collected, it is extracted with water-insoluble organic solvent such as chloroform or benzene, and the extract is concentrated and distilled under
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