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  • Of note, vitamins E and C, carotenoids, and flavonoids may lose their effectiveness as antioxidants or even act as prooxidants under certain circumstances in vitro, for example, at high concentration or high partial pressures of oxygen, in the presence of metal ions such as copper or iron, under mild oxidative condition without coantioxidants, and at a high concentration of carotenoid itself (127-
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