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  • f formula II, then R1 is other than methyl and (i) R3 is selected from hydroxyalkyl, alkoxyalkyl, hydroxyalkoxyalkyl, acylaminoalkyl, and aminoalkyl; and/or (ii) X is other than O; and/or (iii) R1 is (optionally hydroxy-substituted) alkynyl, preferably (optionally hydroxy-substituted) alk-2-ynyl, e.g. prop-2-ynyl, but-2-ynyl, pent-2-ynyl, or 4-hydroxy-but-2-ynyl; and further provided that when R1
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